If you place your VS.Net projects (Windows App) in a network share and try to work off that share, you might end up with an error message like this “The project location is not fully trusted by the .NET runtime”. This message pops up when you try to open the project file. If you say Ok, to that “long” message and continue working you might end up with some security permissions issue when you try to debug. (In my case, I was trying to open a file using StremReader and it threw an Security Exception !)
In order to successfully run the projects, you will need to play around a bit with .Net configuration tool. Launch mscorcfg.msc (you should be able to find this under your current version of .Net Framework dir)
Under My Computer > Runtime Security Policy, you can either add a new code group and give “Full Trust” permission for the URL(File/Http) or you can use the adjust the security policy link, give Full Trust to Local Intranet.
Try one or the other and see what works for you !